Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Serving Per Container: 120
Amount Per Serving
%DV
Curcumin C3 Complex®Turmeric extract (Curcuma longa) (root)standardized to contain 95% Curcuminoids, Including:Bisdemethoxycurcumin (2.2-6.5%)Demethoxycurcumin (15-19%)Curcumin (75-81%)
1000 mg
â€
Black Pepper Ext. (Piper nigrum) (fruit)(standardized to contain 95% Piperine) (BioPerine®)
5 mg
â€
Top Medical Research Studies
9
In a recent clinical trial, we explored the effectiveness of Curcuma zedoaria Rosc., commonly known as turmeric, in treating non-alcoholic fatty liver disease (NAFLD). This condition is alarmingly widespread, affecting a significant portion of the global population. Over the course of 60 days, we compared turmeric with vitamin E, a standard treatment, to see which had better results.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Read More
9
We explored the effects of phytosomal curcumin, a derivative of turmeric, on various physical health indicators in individuals with nonalcoholic fatty liver disease (NAFLD). This analysis sifted through multiple studies, particularly randomized controlled trials, to gauge how effective turmeric extracts might be in managing this condition.
The findings revealed that curcumin could significantly reduce body mass index (BMI), body fat percentage, weight, and waist circumference in participants compared to those who received a placebo. For instance, the average decrease in BMI was notable, with a mean difference of -0.72. These positive impacts suggest that incorporating turmeric can be beneficial for those struggling with weight-related challenges due to NAFLD.
However, curcumin did not show any significant effect on hip circumference or the waist-to-hip ratio, indicating that while there are benefits, not every measure of body composition will respond to treatment. Overall, we observed that phytosomal curcumin stands out as a promising ally in the fight against the complications associated with nonalcoholic fatty liver disease, primarily by improving key anthropometric indices.
The findings revealed that curcumin could significantly reduce body mass index (BMI), body fat percentage, weight, and waist circumference in participants compared to those who received a placebo. For instance, the average decrease in BMI was notable, with a mean difference of -0.72. These positive impacts suggest that incorporating turmeric can be beneficial for those struggling with weight-related challenges due to NAFLD.
However, curcumin did not show any significant effect on hip circumference or the waist-to-hip ratio, indicating that while there are benefits, not every measure of body composition will respond to treatment. Overall, we observed that phytosomal curcumin stands out as a promising ally in the fight against the complications associated with nonalcoholic fatty liver disease, primarily by improving key anthropometric indices.
Read More
Our analysis looked into how curcumin, derived from turmeric, might help those suffering from nonalcoholic fatty liver disease (NAFLD). We reviewed various randomized clinical trials, gathering data from multiple studies to assess its effects on liver enzymes, particularly alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP).
After examining 14 studies, we found promising results for ALT and AST, with curcumin treatment leading to significant reductions in their levels. Specifically, ALT decreased by an average of about 8.72 units, while AST dropped by around 6.35 units. This indicates that curcumin supplementation might indeed benefit liver health by lowering these critical enzyme levels.
On the other hand, when it came to ALP, the results weren't as clear-cut. Our pooled analysis showed no significant effect on ALP levels overall. However, further exploration revealed that patients who took curcumin for longer periods saw some benefits in their ALP readings.
In conclusion, our findings suggest that curcumin could play a useful role in managing liver health in individuals with NAFLD, particularly in reducing certain liver enzymes. However, we believe further studies are essential to fully understand these effects and offer clearer guidelines for supplementation.
After examining 14 studies, we found promising results for ALT and AST, with curcumin treatment leading to significant reductions in their levels. Specifically, ALT decreased by an average of about 8.72 units, while AST dropped by around 6.35 units. This indicates that curcumin supplementation might indeed benefit liver health by lowering these critical enzyme levels.
On the other hand, when it came to ALP, the results weren't as clear-cut. Our pooled analysis showed no significant effect on ALP levels overall. However, further exploration revealed that patients who took curcumin for longer periods saw some benefits in their ALP readings.
In conclusion, our findings suggest that curcumin could play a useful role in managing liver health in individuals with NAFLD, particularly in reducing certain liver enzymes. However, we believe further studies are essential to fully understand these effects and offer clearer guidelines for supplementation.
Read More
Most Useful Reviews
8
Inflammation reduction
9 people found this helpful
NIH studies indicated Turmeric works for both kidneys and fatty liver disease. I noticed pain relief for my arthritis when taking a high-quality extract, though I had to adjust to avoid stomach pain. It’s been worth it, especially as it helps my condition without harming my kidneys.
Read More
0
Avoid turmeric supplements
2 people found this helpful
WARNING - do not take this supplement or any other turmeric/curcumin supplement. Turmeric supplements cause serious liver damage. I took this for two weeks and experienced SEVERE upper abdominal bloating and pressure. I ceased the supplement and within 24 hours the discomfort vanished. Long-term use can lead to autoimmune liver disease or cirrhosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
- All Researches
9.5
We explored the use of curcumin, a compound found in turmeric, in treating acute liver injury (ALI). To enhance curcumin's effectiveness, we created a specialized delivery system using human serum albumin (HSA) that releases curcumin in response to reactive oxygen species (ROS), which are often elevated during inflammation. This system was then cloaked with macrophage membranes to improve targeting to inflamed liver tissues.
Our results showed that this innovative approach allowed the curcumin to be effectively delivered to the injured liver, where it significantly reduced ROS levels and the production of pro-inflammatory cytokines. This suggests that curcumin can help alleviate inflammation during ALI by shifting the balance of immune responses.
We found that the delivery system helped protect liver cells from oxidative stress and promoted a shift in the immune response, which is a vital part of recovery from liver injury. Overall, we observed promising outcomes that position this curcumin delivery method as a potential therapy for managing acute liver injury.
Our results showed that this innovative approach allowed the curcumin to be effectively delivered to the injured liver, where it significantly reduced ROS levels and the production of pro-inflammatory cytokines. This suggests that curcumin can help alleviate inflammation during ALI by shifting the balance of immune responses.
We found that the delivery system helped protect liver cells from oxidative stress and promoted a shift in the immune response, which is a vital part of recovery from liver injury. Overall, we observed promising outcomes that position this curcumin delivery method as a potential therapy for managing acute liver injury.
Read More
9
We explored the effects of phytosomal curcumin, a derivative of turmeric, on various physical health indicators in individuals with nonalcoholic fatty liver disease (NAFLD). This analysis sifted through multiple studies, particularly randomized controlled trials, to gauge how effective turmeric extracts might be in managing this condition.
The findings revealed that curcumin could significantly reduce body mass index (BMI), body fat percentage, weight, and waist circumference in participants compared to those who received a placebo. For instance, the average decrease in BMI was notable, with a mean difference of -0.72. These positive impacts suggest that incorporating turmeric can be beneficial for those struggling with weight-related challenges due to NAFLD.
However, curcumin did not show any significant effect on hip circumference or the waist-to-hip ratio, indicating that while there are benefits, not every measure of body composition will respond to treatment. Overall, we observed that phytosomal curcumin stands out as a promising ally in the fight against the complications associated with nonalcoholic fatty liver disease, primarily by improving key anthropometric indices.
The findings revealed that curcumin could significantly reduce body mass index (BMI), body fat percentage, weight, and waist circumference in participants compared to those who received a placebo. For instance, the average decrease in BMI was notable, with a mean difference of -0.72. These positive impacts suggest that incorporating turmeric can be beneficial for those struggling with weight-related challenges due to NAFLD.
However, curcumin did not show any significant effect on hip circumference or the waist-to-hip ratio, indicating that while there are benefits, not every measure of body composition will respond to treatment. Overall, we observed that phytosomal curcumin stands out as a promising ally in the fight against the complications associated with nonalcoholic fatty liver disease, primarily by improving key anthropometric indices.
Read More
9
We explored the effects of Tetrahydrocurcumin (THC), a compound derived from turmeric, on liver disease, specifically focusing on metabolic dysfunction-associated steatohepatitis (MASH). The study involved C57BL/6 mice that were subjected to a methionine-choline-deficient diet for eight weeks to induce MASH. We administered THC to one group of mice while another group received obeticholic acid as a positive control.
After treatment, we observed several promising outcomes. THC significantly reduced oxidative stress and fat accumulation in liver cells, lessened liver injury, and improved overall liver health in the mice. It also corrected 34 different lipid imbalances brought on by the diet, enhancing the diversity and abundance of beneficial gut bacteria while lowering harmful strains linked to obesity.
Additionally, bile acid analysis showed THC decreased the levels of certain toxic bile acids in the serum that can harm the liver. Importantly, THC also influenced gene expression related to fat production and bile acid secretion, indicating a multifaceted approach to combating liver issues. Overall, this research suggests that THC may be a valuable compound in promoting liver health and offers insights for future treatments targeting MASH.
After treatment, we observed several promising outcomes. THC significantly reduced oxidative stress and fat accumulation in liver cells, lessened liver injury, and improved overall liver health in the mice. It also corrected 34 different lipid imbalances brought on by the diet, enhancing the diversity and abundance of beneficial gut bacteria while lowering harmful strains linked to obesity.
Additionally, bile acid analysis showed THC decreased the levels of certain toxic bile acids in the serum that can harm the liver. Importantly, THC also influenced gene expression related to fat production and bile acid secretion, indicating a multifaceted approach to combating liver issues. Overall, this research suggests that THC may be a valuable compound in promoting liver health and offers insights for future treatments targeting MASH.
Read More
9
In a recent clinical trial, we explored the effectiveness of Curcuma zedoaria Rosc., commonly known as turmeric, in treating non-alcoholic fatty liver disease (NAFLD). This condition is alarmingly widespread, affecting a significant portion of the global population. Over the course of 60 days, we compared turmeric with vitamin E, a standard treatment, to see which had better results.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Read More
9
We investigated a promising approach to tackle liver fibrosis, a serious condition linked to chronic liver diseases. Our focus was on curcumin, a compound found in turmeric, and its ability to be effectively delivered to the liver using innovative nanocarriers.
Our study utilized a specially designed delivery system that paired curcumin with a metal-based substance known as Cu-coordinated mesoporous polydopamine (CMP). This combination not only aimed to harness the antifibrotic properties of curcumin but also to address the buildup of harmful reactive oxygen species (ROS) that contribute to liver damage.
We found that the CMP carried curcumin efficiently while improving its antioxidant abilities, leading to better cellular uptake. Importantly, tests showed that this nanodrug significantly reduced the proliferation of liver cells that lead to fibrosis and effectively scavenged harmful ROS without harmful effects on healthy cells.
In vivo studies demonstrated that the combination of curcumin and CMP reduced collagen deposits, alleviating liver fibrosis while maintaining safety. This highlights the potential of using turmeric-derived curcumin in targeted treatments for liver diseases, paving the way for better therapeutic strategies.
Our study utilized a specially designed delivery system that paired curcumin with a metal-based substance known as Cu-coordinated mesoporous polydopamine (CMP). This combination not only aimed to harness the antifibrotic properties of curcumin but also to address the buildup of harmful reactive oxygen species (ROS) that contribute to liver damage.
We found that the CMP carried curcumin efficiently while improving its antioxidant abilities, leading to better cellular uptake. Importantly, tests showed that this nanodrug significantly reduced the proliferation of liver cells that lead to fibrosis and effectively scavenged harmful ROS without harmful effects on healthy cells.
In vivo studies demonstrated that the combination of curcumin and CMP reduced collagen deposits, alleviating liver fibrosis while maintaining safety. This highlights the potential of using turmeric-derived curcumin in targeted treatments for liver diseases, paving the way for better therapeutic strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
8
Inflammation reduction
9 people found this helpful
NIH studies indicated Turmeric works for both kidneys and fatty liver disease. I noticed pain relief for my arthritis when taking a high-quality extract, though I had to adjust to avoid stomach pain. It’s been worth it, especially as it helps my condition without harming my kidneys.
Read More
0
Avoid turmeric supplements
2 people found this helpful
WARNING - do not take this supplement or any other turmeric/curcumin supplement. Turmeric supplements cause serious liver damage. I took this for two weeks and experienced SEVERE upper abdominal bloating and pressure. I ceased the supplement and within 24 hours the discomfort vanished. Long-term use can lead to autoimmune liver disease or cirrhosis.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Petagine L, Zariwala MG, Somavarapu S, Chan SHY, Kaya EA, et al. Oxidative stress in a cellular model of alcohol-related liver disease: protection using curcumin nanoformulations. Sci Rep. 2025;15:7752. 10.1038/s41598-025-91139-0
- Elizalde MM, Fuentes P, Chiappetta D, Flichman DM. Contrasting Effect of Curcumin on Hepatitis B Virus Replication According to the Hepatoma Cell Line. Pathogens. 2025;14. 10.3390/pathogens14020203
- Liu N, Li H. Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis. Medicine (Baltimore). 2024;103:e40538. 10.1097/MD.0000000000040538
- Hamouda MAB, Saad AH, El-Saadany AAEAE, El Sharawey TMHA, Abdo W, et al. Trials for reducing the dangerous effect on poultry fed on aflatoxin contaminated ration using nano curcumin. BMC Vet Res. 2025;21:72. 10.1186/s12917-025-04519-z
- Hemati S, Mehrabinejad F, Elhaie M, Najafizade N. Curcumin Supplementation as a Preventive Strategy Against Tamoxifen-Induced Nonalcoholic Fatty Liver Disease in ER+ Breast Cancer Patients: A Triple-Blind Randomized Placebo-Controlled Trial. J Diet Suppl. 2025;22:274. 10.1080/19390211.2025.2465412
- Peng S, Meng M, Luo P, Liu J, Wang J, et al. Tetrahydrocurcumin Alleviates Metabolic Dysfunction-Associated Steatohepatitis in Mice by Regulating Serum Lipids, Bile Acids, and Gut Microbiota. Int J Mol Sci. 2025;26. 10.3390/ijms26030895
- Handu D, Stote K, Piemonte T. Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a Systematic Scoping Review. Nutrients. 2025;17. 10.3390/nu17030453
- Feng JN, Shao W, Yang L, Pang J, Ling W, et al. Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice. Nutr Diabetes. 2025;15:4. 10.1038/s41387-025-00363-0
- Ashraf A, Rather SA, Mehraj M. "Evaluation of Curcuma zedoaria Rosc. in the management of non-alcoholic fatty liver Disease: A Randomized, single blind, controlled trial". Arab J Gastroenterol. 2025;26:112. 10.1016/j.ajg.2025.01.004
- Liu X, Mu X, Wang Y, Liu Z, Li Y, et al. Metal-based mesoporous polydopamine with dual enzyme-like activity as biomimetic nanodrug for alleviating liver fibrosis. J Colloid Interface Sci. 2025;684:586. 10.1016/j.jcis.2025.01.081
- Ebrahimzadeh A, Ebrahimzadeh A, Fooladshekan S, Mohseni S, Mohtashamian A, et al. Therapeutic effects of curcumin supplementation on liver enzymes of nonalcoholic fatty liver disease patients: A systematic review and meta-analysis of randomized clinical trials. Food Sci Nutr. 2025;13:e4144. 10.1002/fsn3.4144
- Hu D, Huang Z, Li W, Shan L, Wu MY, et al. Macrophage Membrane-Cloaked ROS-Responsive Albumin Nanoplatforms for Targeted Delivery of Curcumin to Alleviate Acute Liver Injury. Mol Pharm. 2025;22:771. 10.1021/acs.molpharmaceut.4c00808
- Lee SO, Chu KB, Yoon KW, Heo SI, Song JH, et al. Combinatorial Treatment with Praziquantel and Curcumin Reduces Parasite Burden and Clonorchiasis-Associated Pathologies in Rats. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16121550
- Huang Q, An Z, Xin X, Gou X, Tian X, et al. The Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta-Analysis. Food Sci Nutr. 2024;12:10010. 10.1002/fsn3.4595
- Ranneh Y, Bedir AS, Abu-Elsaoud AM, Al Raish S. Polyphenol Intervention Ameliorates Non-Alcoholic Fatty Liver Disease: An Updated Comprehensive Systematic Review. Nutrients. 2024;16. 10.3390/nu16234150
- Wu Y, Guo F, Ma Y, Chai W, Li J, et al. Curcumin's Protective Role in Heatstroke-Induced Acute Liver Injury: Targeting Pyroptosis and Enhancing SIRT1 Expression. Glob Chall. 2024;8:2400178. 10.1002/gch2.202400178
